Melatonin users have 90% higher chance of developing heart failure, twice as likely to die: New study | Mint

Melatonin Linked to Higher Heart Failure Risk, Study Finds

A recent study presented at the American Heart Association (AHA) Scientific Sessions 2025 reports that extended melatonin use may significantly raise the risk of heart failure among adults with insomnia.

Findings and Risk Increase

Researchers analyzed data from over 130,000 adults diagnosed with insomnia but without any prior heart failure history. The results showed that those who used melatonin for more than a year faced about a 90% higher likelihood of developing heart failure within five years compared to non-users.

Long-term melatonin users were nearly 3.5 times more likely to be hospitalized for heart failure compared with nonusers.

In addition, chronic users were at greater risk of dying from any cause during the same period.

Usage and Regional Differences

Melatonin remains one of the most popular over-the-counter sleep aids in the United States, with almost six million Americans depending on it to fall asleep or stay asleep longer. In contrast, in the United Kingdom it can only be obtained by prescription, and even there, individuals filling at least two prescriptions spaced 90 days apart still displayed an 82% higher risk of heart failure.

Research Context

The study emphasizes the need for caution among regular melatonin users, especially those self-medicating for sleep issues. While melatonin is often considered a safe and natural option, its long-term cardiovascular effects may be more serious than previously understood.

Author’s summary: Long-term melatonin use significantly increases the risk of heart failure and mortality, urging caution for adults who regularly rely on it for sleep.

more

Mint Mint — 2025-11-07

More News