Heart Health: Long-Term Melatonin Use Linked to Cardiovascular Risk

Recent research indicates that individuals with insomnia who take melatonin supplements for over a year may face a higher risk of heart failure compared to those who do not use this common sleep aid.

Study Findings

The researchers found that those using melatonin for more than a year were more likely to be diagnosed with heart failure, require hospitalization for the condition, or die from any cause. This study was presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans, though it has not yet undergone peer review.

Research Limitations and Safety Concerns

The study does not prove a cause-and-effect relationship between melatonin use and heart failure risk. However, it raises concerns about the safety of long-term melatonin supplementation and suggests the need for further investigation.

Regulation and Usage

Many melatonin supplements are available over the counter without prescriptions and lack regulation, allowing people to use them without medical supervision.

“Melatonin supplements may not be as harmless as commonly assumed.”

Author's summary: Long-term melatonin supplementation may carry cardiovascular risks, highlighting the need for careful use and further research on its safety.

Healthline — 2025-11-05