Invincible co-creator Robert Kirkman revealed that Season 4 will introduce a brand new story not seen in the comics.
The new story will take place in Season 4's fourth episode, which Kirkman directly wrote.
I wrote the fourth episode.
Invincible's third season adapted the comics run closely, but the post-credits scene featured a returning character, leading into the new story.
Author's summary: Invincible Season 4 has a new story.