Model Establishes Framework for Designing Drugs to Prevent Neurodegenerative Disorders
Analytical model describes the aggregation of amyloid-forming proteins via lipid-mediated interactions.
Many neurodegenerative disorders, such as Parkinson’s disease, share the hallmark of functional proteins forming deposits known as amyloid fibrils in a process that can be modulated by the presence of lipids.
A theoretical model of lipid-induced aggregation has been developed with the aim of creating a tool that can be used to inform the design of anti-aggregation drugs.
The analytical model accounts for lipid-mediated interactions in terms of kinetic equations for the surface coverage of monomers and aggregates.
Author's summary: Model helps design drugs for neurodegenerative disorders.