Nanopore Sensor Detects Individual Volatile Organic Compounds
Technology could be used to detect subtle shifts in bodily markers in breath that herald infections and cancers.
A nanopore-based technology has been developed, capable of detecting single molecules in real time, a major step toward fast, low-cost chemical profiling.
Using engineered protein pores, the new approach targets aldehydes by briefly binding them inside nanoscale channels, leading to distinct electrical signals that reveal their chemical identity and abundance.
Aldehydes are important markers of human health, belonging to a wider family of volatile organic compounds (VOCs) released in breath and bodily fluids, where shifts in their relative levels have been linked to diseases, such as cancer, respiratory disorders, and viral infections like Covid-19.
Volatiles in breath could be used to detect disease by an accurate chemical sensor.
Author's summary: Nanopore sensor detects individual VOCs.
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